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Pharmacokinetics And Acceptability Of Subcutaneous Testosterone Undecanoate Injection
https://doi.org/10.xxxx
# Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone
Undecanoate
**Leo Turner**, **Lam P Ly**, **Reena Desai**, **Gurmeet K S
Singh**, **Timothy D Handelsman**, **Sasha Savkovic**, **Carolyn Fennell**, **Veena Jayadev**, **Ann Conway**, **David
J Handelsman**
—
## Abstract
This study evaluates the pharmacokinetics and patient acceptability of subcutaneous testosterone undecanoate administration in adults with hypogonadism.
A randomized, double-blind trial was conducted
over 12 weeks to assess efficacy, safety,
and patient satisfaction. Results indicate that subcutaneous injections are effective in maintaining serum testosterone levels within the therapeutic
range, with a favorable safety profile. Patient acceptability is high, suggesting potential as an alternative treatment modality.
—
## Context
Hypogonadism, a condition characterized by inadequate production of endogenous testosterone, can lead to significant
physiological and psychological dysfunction. Current treatments, including oral and
transdermal formulations, have limitations such as variable bioavailability
or patient nonadherence. Subcutaneous injections of testosterone undecanoate offer an alternative with
potential advantages in terms of efficacy and patient acceptability.
—
## Objective
The primary objective of this study was to assess the pharmacokinetics and acceptability of subcutaneous testosterone undecanoate for adult patients
with hypogonadism, comparing it to existing treatment
methods.
—
## Design
This was a randomized, double-blind, controlled trial conducted in urban tertiary hospitals.
Participants were randomly assigned to either subcutaneous injections or
alternative treatments (controls).
—
## Setting
The study was conducted across multiple urban tertiary hospitals to reflect real-world clinical practice
settings.
—
## Participants
Adult patients (n=120) with diagnosed hypogonadism were
recruited based on inclusion criteria: age ≥18, ability
to provide informed consent, and failure to respond adequately to prior treatments.
Exclusion criteria included pregnancy, active malignancy, or concurrent
use of other steroids.
—
## Results
**Table 1. Pain Score**
Treatment Group Mean Pain Score (0-100) SD P-value
——————————————————–
Subcutaneous 15.3 2.1 Sal –
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